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Medication

Diphenhydramine in US EMS protocols

230protocols
192named agencies
51states and regions
8indications
1,389dose entries
100% of 1,389machine-parsed

Includes 2 agencies outside the US.

IndicationSpread: box is the middle half, dot means most agreeRange
Agitation Adult25 to 50 mg median 37.5, n=13 median matches NASEMSO
Pediatric, weight-basedAll use 1 mg/kg n=5
Allergic reaction Adult12.5 to 50 mg median 37.5, n=149
Adult, weight-basedAll use 1 mg/kg matches NASEMSO n=11
Pediatric6.25 to 25 mg median 12.5, n=7
Pediatric, weight-basedMost use 1 mg/kg matches NASEMSO range 0.5 to 2 mg/kg, n=146
Anaphylaxis Adult12.5 to 50 mg median 37.5, n=84
Adult, weight-basedAll use 1 mg/kg matches NASEMSO n=8
Pediatric, weight-basedMost use 1 mg/kg matches NASEMSO range 0.5 to 2 mg/kg, n=87
Dystonic reaction Adult12.5 to 50 mg median 37.5, n=123
Adult, weight-basedAll use 1 mg/kg n=9
Pediatric, weight-basedMost use 1 mg/kg range 0.5 to 1.5 mg/kg, n=104
Nausea / vomiting Adult12.5 to 50 mg median 25, n=37 median matches NASEMSO
Pediatric, weight-basedMost use 1 mg/kg range 0.5 to 1.25 mg/kg, n=23
Other Adult11.25 to 50 mg median 25, n=99
Adult, weight-basedMost use 1 mg/kg range 0.5 to 1 mg/kg, n=15
Pediatric12.5 to 50 mg median 23.75, n=8
Pediatric, weight-basedMost use 1 mg/kg range 0.5 to 1.5 mg/kg, n=89
Procedural sedation Pediatric, weight-basedAll use 1 mg/kg n=7

Too few protocols to chart yet (protocols in brackets): Hyperactive delirium (1)

Doses far off from what other protocols give are likely misreads, so they are left out until checked. How that works.

Named agencies with a page187

Agencies whose protocols are a public record are named here. Their own doses are on their own pages; this list carries no values.

Cite this

United States EMS Protocol Census, Diphenhydramine: n=230 protocols from 192 named agencies / 51 states, as of 2026-10-31

MethodologyData licenseStudy your own protocol in the app

Training reference compiled from published protocols. Not a clinical order. Verify with your agency and medical director.