Diphenhydramine for Agitation
Adult dosing has a median of 37.5 mg across 13 published protocols, with the middle half between 25 and 50.
Doses far off from what other protocols give are likely misreads, so they are left out until checked. How that works.
Adultmg
| min | p25 | median | p75 | max |
|---|---|---|---|---|
| 25 | 25 | 37.5 | 50 | 50 |
Values in mg. One value per source (that source's median), so a document listing a medication five times still gets one vote.
Routes
- IM 38%
- IV 19%
- IV/IM 19%
- IV/IO/IM 19%
- IV/IO 6%
United States EMS Protocol Census, n=13 protocols from 13 named agencies / 10 states, updated Oct 2026
Pediatric, weight-basedmg/kg
| min | p25 | median | p75 | max |
|---|---|---|---|---|
| 1 | 1 | 1 | 1 | 1 |
Values in mg/kg. One value per source (that source's median), so a document listing a medication five times still gets one vote.
Routes
- IV/IM 40%
- IV/IO/IM 40%
- IM 20%
United States EMS Protocol Census, n=5 protocols from 5 named agencies / 5 states, updated Oct 2026
Named agencies with a page13
Agencies whose protocols are a public record are named here. Their own doses are on their own pages; this list carries no values.
- Alabama Department of Public Health Office of Emergency Medical Services
- Department of Aviation Medicine
- Lane County Medical Control Board
- Montana Board of Medical Examiners
- National Emergency Medical Services
- Nebraska Medicine Division of Prehospital and Emergency Medical Services
- Nevada EMS Program
- North Central Oregon EMS Agencies
- Northeast Ohio Regional EMS Protocol Committee
- Ocala/Marion County/The Villages Public Safety EMS
- Peninsulas EMS Council, Inc.
- REMSA
- State of Nebraska