Diphenhydramine for Anaphylaxis
Pediatric weight-based dosing has a median of 1 mg/kg across 87 published protocols, with the middle half between 1 and 1.
Includes 1 agency outside the US.
Doses far off from what other protocols give are likely misreads, so they are left out until checked. How that works.
Pediatric, weight-basedmg/kg
| min | p25 | median | p75 | max |
|---|---|---|---|---|
| 0.5 | 1 | 1 | 1 | 2 |
Values in mg/kg. One value per source (that source's median), so a document listing a medication five times still gets one vote.
Routes
- IV/IO/IM 40%
- IV/IM 23%
- IM 9%
- IV 9%
- IV/IM/PO 7%
- PO 7%
- IV/IO 5%
- IV/IO/IM/PO 2%
United States EMS Protocol Census, n=87 protocols from 69 named agencies / 36 states, updated Oct 2026
Adultmg
| min | p25 | median | p75 | max |
|---|---|---|---|---|
| 12.5 | 25 | 37.5 | 50 | 50 |
Values in mg. One value per source (that source's median), so a document listing a medication five times still gets one vote.
Routes
- IV/IO/IM 39%
- IV/IM 20%
- IM 11%
- IV 11%
- PO 8%
- IV/IO 6%
- IV/IM/PO 5%
- IV/IO/IM/PO 2%
United States EMS Protocol Census, n=84 protocols from 67 named agencies / 34 states, updated Oct 2026
Adult, weight-basedmg/kg
| min | p25 | median | p75 | max |
|---|---|---|---|---|
| 1 | 1 | 1 | 1 | 1 |
Values in mg/kg. One value per source (that source's median), so a document listing a medication five times still gets one vote.
Routes
- IV/IM 50%
- IV/IM/PO 25%
- IV/IO/IM 25%
United States EMS Protocol Census, n=8 protocols from 6 named agencies / 6 states, updated Oct 2026
Named agencies with a page73
Agencies whose protocols are a public record are named here. Their own doses are on their own pages; this list carries no values.
- Academy of Medicine of Cincinnati
- Ada County-City Emergency Services System
- BC Emergency Health Services
- Benbrook Fire Department
- BEST EMS
- Boulder County Protocol Committee
- Brilliant Fire Department
- Cabarrus County EMS
- Campbell County Emergency Medical Service
- Central California Emergency Medical Services
- Chaves County EMS
- Chelan/Douglas/Okanogan/Grant County
- Clark County EMS (Washington)
- Coastal Valleys EMS Agency
- Confederated Tribes of Grand Ronde Department of Emergency Services
- Coos County Emergency Medical Services
- Davidson County Emergency Services
- DC Fire and EMS
- Department of Aviation Medicine
- East Baton Rouge Parish Department of Emergency Medical Services
- El Campo Emergency Medical Service
- EMS Region VII Bioterrorism and All Hazards Preparedness Committee
- Fern Creek Fire and Emergency Medical Services
- FirstHealth of the Carolinas
- Franklin County Emergency Medical Services
- Giles County EMS
- Grant County
- Greenville County Emergency Medical Services
- Illinois Emergency Medical Services for Children
- Illinois Region VIII Emergency Medical Services
- Kern County Public Health
- Kosciusko County Paramedics
- Lane County Medical Control Board
- Laurens County Emergency Medical Services
- Levy County Department of Public Safety
- Maine Emergency Medical Services
- County of Marin EMS
- Maryland Institute for Emergency Medical Services Systems
- Mauston Area Ambulance
- McKinney Fire Department
- Michigan Department of Health and Human Services (MDHHS) / Midland Gladwin MCA
- Michigan Department of Health and Human Services (MDHHS) / West Michigan Regional MCC
- Miramar Fire Rescue Department
- Montana Board of Medical Examiners
- Nash County Emergency Medical Services
- National Emergency Medical Services
- New Jersey Department of Health
- Northeastern Montana Stat Air Ambulance Cooperative
- Nueces County ESD4
- Office of the EMS Medical Director for Kansas City, Missouri
- Okaloosa County EMS
- Old Dominion EMS Alliance, Inc.
- Palm Beach Gardens Fire Rescue
- Pend Oreille County Emergency Medical Services
- Pettis County Ambulance District
- Region One Metropolitan Ambulance Council
- Region X EMS
- Regional Emergency Medical Advisory Committee of New York City
- REMSA Sioux Falls
- Reno County Emergency Medical Services
- Salem Fire Department
- Sierra – Sacramento Valley EMS Agency
- Southern Fox Valley EMS System
- Spokane County EMS
- Stanislaus County Emergency Medical Services Agency
- Stevens County Emergency Medical Services
- Tennessee Emergency Medical Services
- Tri County Emergency Medical Services, Inc.
- Virgin Islands Fire & Emergency Medical Services
- Wake County EMS System
- Washington County Emergency Medical Services
- Wilson County Emergency Management Agency
- Wilson County ESD #4